Servier Canada
Oncaspar®
ONCASPAR logo; ONCASPAR pegaspargase injection.

Therapeutic drug monitoring (TDM)

Guidance on TDM from the ONCASPAR® Product Monograph:1

  • Measurement of the L-asparaginase activity level in serum or plasma may be undertaken in order to rule out an accelerated reduction of L-asparaginase activity.
  • Low L-asparaginase activity levels are often accompanied by the appearance of anti-L-asparaginase antibodies. In such cases, a switch to a different L-asparaginase preparation should be considered. Expert advice should first be sought.
  • The decrease in the number of circulating lymphoblasts is often quite marked, and normal or too low leukocyte counts are often seen in the first days after the start of therapy. To monitor the therapeutic effect, the peripheral blood count and the patient’s bone marrow should be monitored closely.

Please consult the ONCASPAR® Product Monograph for full recommendations on TDM.

Learn more about ONCASPAR®

aBFM: augmented Berlin-Frankfurt-Münster; ALL: acute lymphoblastic leukemia; BSA: body surface area; CNS: central nervous system; CSF: cerebrospinal fluid; DFCI: Dana-Farber Cancer Institute; ELISA: enzyme-linked immunosorbent assay; IM: intramuscular; IV: intravenous; PD: pharmacodynamics; PK: pharmacokinetics; NCCN: National Comprehensive Cancer Network®; TDM: therapeutic drug monitoring.

* Clinical significance has not been established.

† Comparative clinical significance has not been established.

‡ Fictitious cases. May not be representative of all patients.

§ Native E. coli L-asparaginase is not available in Canada.

References: 

  1. ONCASPAR® Product Monograph. Servier Canada. August 20, 2024.
  2. ONCASPAR_CPID Redacted.
  3. ASPARLAS® Product Monograph. Servier Canada. March 8, 2024.
  4. RYLAZE™ Product Monograph. Jazz Pharmaceuticals Canada Inc.
  5. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Acute Lymphoblastic Leukemia V.2.2024. Available at: https://www.nccn.org/professionals/physician_gls/pdf/all.pdf. Accessed November 8, 2024.
  6. Vrooman LM et al. Efficacy and toxicity of pegaspargase and calaspargase pegol in childhood acute lymphoblastic leukemia: Results of DFCI 11-001. J Clin Oncol. 2021;39(31):3496–3505.
Back to top

Stay Connected with Servier Canada

Stay up to date on disease information, treatment options, our products, and patient support programs.

Sign Up